Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study
academic.oup.com/ijnp/article/11/3/413/761288
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Chronic nicotine exposure was reported to reduce the sensitivity of GABA receptors and result in disinhibition of midbrain dopamine neurons (Amantea and Bowery, 2004). Chronic nicotine administration was also reported to increase the level of ionotropic glutamate receptors in the midbrain and conceivably enhance the excitatory input to the midbrain
Enhanced striatal dopamine release in smokers might be a consequence of altered control of dopamine release after repeated nicotine exposure.
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