Pooled optical genetic screening in human cells
ngle cell genomic and functional analysis, drug screening, and genomic screening by combining diverse molecular, optical, and microfluidic technologies.
Scalable combinatorial screening
Accurate and sensitive measurement of somatic mutation flow across cells
Robust and accurate systems for single-cell genomics at scale
d in situ sequencing
This capability reduces the cost for spatially and temporally-resolved screens by multiple orders of magnitude and extends large-scale pooled screening into new biological models and disease areas.
robustness, compartmentalization of small-molecule solutes, and integration with imaging that enabled the first large-scale application of micro-droplets for drug screening.
synergize to re-activate antibiotic drugs against Gram-negative bacterial pathogen
The group developed one method based on a new microfluidics concept we call virtual microfluidics that eliminates the dependence on specialized equipment and a molecular enrichment method that makes a 100-fold improvement in sensitivity/throughput for rare target cells in pooled single-cell RNA-seq libraries
My group developed a concept to jointly analyze variants across samples related by a lineage prior (rather than one at a time) to improve the sensitivity and specificity of somatic mutation detection and resolve such events in individual related cells.
Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.