Module 4-L2: Discussion (5/7): Clinical Pharmacy and Pharmacotherapeutics 1-CMSANCHEZ
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Precipitation
Lipid destabilization
Potential to infuse solid particles to the narrow pulmonary capillaries
may result in fatal emboli &
nutrients may not be infused to the patient.
O/W lipid emulsions are sensitive to destabilization
presence of positively charged
ions
pH changes
) changes in environmental temperature.
admixture by drawing the negatively charged
increasing their tendency to join or coalesce.
Low concentrations of amino acids
reduce the stability of the emulsion
increase the tendency for creaming and cracking of the lipid emulsion
Oxidation of Vitamin C
least stable component
marker for vitamin degradation
Photolysis of Vitamin A
Photo-oxidation of vitamin E
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