PA-17-444: Ethical, Legal, and Social Implications (ELSI) of Genomics Research Project Grant Program (R01)

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• supporting research that seeks to understand or address mechanisms and pathways that contribute to health disparities in genomic medicine.

• NICHD has specific interest in research that addresses a range of ethical, legal and social issues for individuals and communities related to genetic and genomic research involving the following areas:

• e distinctions between basic and clinical genomic research blur, and new findings are altering the practice of medicine.

• he purpose of this FOA is to solicit research applications that identify, analyze, and address the ethical, legal and social implications (ELSI) of these genetic and genomic advances for individuals, families, communities and society more broadly.

• multi-disciplinary studies using either single or mixed methods.

• Applicants are strongly encouraged to contact ELSI program officials prior to developing an application.

• fall roughly into the following broad domains

• Data Stewardship and Sharing  Inclusion of Diverse Populations in Research

• Legal and Regulatory Issues in Genomic Research

• Genomic Medicine and Health Disparities

• Genomic Medicine in Diverse Healthcare Settings

• Precision Medicine and Genomics

• Genomics and Conceptions of Human Identity and Origins

• e ethical, legal and social issues related to cancer and genomics. In

• implications of using genomic technology to identify genetic causes of disease and disability that may or may not have available treatments

• must focus on one or more U.S. minority or health disparity populations (A

• esearch may use available secondary data, health system data and/or collection of primary data.

• elf-identified race and ethnicity (SIRE) and ancestry informative markers (AIMs) in genomics and biomedical research to enhance ability to describe research participants’ diverse backgrounds and experiences in scientifically and socially meaningful ways.

• creation of linguistic guidelines for discussing social categories and reporting on population variability and health disparities.

• address cultural and structural barriers and facilitators to enable research participation f