MRI of the brain 75% Optic glioma is the CNS tumor most commonly associated with NF1 and typically develops before the age of six years. Although this tumor is usually asymptomatic, patients may present with visual abnormalities, including proptosis, decreased color vision, and/or decreased visual acuity. All patients with NF1 and visual symptoms should undergo MRI of the brain with contrast for further evaluation. In addition, all children with NF1 should undergo an annual ophthalmologic examination to screen for optic glioma.
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