The Uronium/Guanidinium Peptide Coupling Reagents: Finally the True Uronium Salts
onlinelibrary-wiley-com.ezproxy.auckland.ac.nz/doi/full/10.1002/1521-3773(20020201)41:3%3C441::AID-ANIE441%3E3.0.CO;2-N
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A year later, X-ray crystallographic analysis and solution and solid-state NMR spectroscopy showed that the true structures in both the crystalline state6 and in solution7, 8 were the guanidinium isomers 2 and not the uronium isomers 1.
new uronium salts are more efficient coupling reagents than the corresponding guanidinium isomers.
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