new research organism in the aging field
turquoise killifish, a vertebrate with a naturally compressed lifespan of only 4–6 months, fills an essential gap to understand aging.
Understanding the diapause state could give new insights into strategies to prevent the damage caused by aging and to better preserve organs, tissues, and cells.
compressed lifespan and a long-term resistant diapause state,
exhibiting exceptional resistance to stress and to damages due to the passage of time.
allows more systematic characterizations of the interplay between genetics and environment during vertebrate aging.
Diapause and nondiapause embryos provide a set of potent experimental materials to gain insight into not only the regulation of diapause but also the changes in the aging process during and beyond diapause.
In other documented examples of insects, individuals that have been through diapause significantly even outlive their counterparts that have never entered diapause (Tatar & Yin, 2001). Thus, the aging process appears to be slowed down or even suspended during diapause
Thus, studying diapause could not only offer insight into the genetic network that regulates lifespan but also provide new ideas for prevention of damage accumulation or erasure of damage.
Diapause can occur at different developmental stages in diverse species
In killifishes, diapause can occur during early, intermediate, and late developmental stages (diapause I, II, and III, respectively;
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