Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence - PubMed
pubmed.ncbi.nlm.nih.gov/20605919/
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progerin induces early senescence associated with increased DNA-damage signaling and that telomerase extends HGPS cellular lifespan
telomerase extends HGPS cellular lifespan by decreasing progerin-induced DNA-damage signaling and activation of p53 and Rb pathways
progerin-induced DNA-damage signaling is localized to telomeres and is associated with telomere aggregates and chromosomal aberrations
HGPS premature cellular senescence results from progerin-induced telomere dysfunction.
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