Overview on Epigenetic Re-programming: A Potential Therapeutic Intervention in Triple Negative Breast Cancers - PubMed


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  • Hypothetically, upon administration of epigenetic drugs, recovery of tumour suppressor genes is expected. However, high tendency of switching on global metastatic genes is predicted.

  • Polycomb repressive complex (PRC) such as EZH2

  • is known to have repressive effects in gene regulation and shown to inhibit cell proliferation and invasion in breast cancers.

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