Overview on Epigenetic Re-programming: A Potential Therapeutic Intervention in Triple Negative Breast Cancers - PubMed
pubmed.ncbi.nlm.nih.gov/30583339/
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Hypothetically, upon administration of epigenetic drugs, recovery of tumour suppressor genes is expected. However, high tendency of switching on global metastatic genes is predicted.
Polycomb repressive complex (PRC) such as EZH2
is known to have repressive effects in gene regulation and shown to inhibit cell proliferation and invasion in breast cancers.
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