t epigenetic regulation to the forefront of memory research, revealing potential novel therapeutic approache
nderstanding the transcriptomic and epigenomic landscape in the major brain cell types in both normal physiological brain function and under pathological disease states
using a mouse model of severe neurodegeneration,
th substantial contribution to the genetic risk for Alzheimer’s disease (AD).
conducted single cell RNA-sequencing of microglia during multiple stages of neurodegeneration in a severe neurodegeneration mouse mode
performing cell type-specific epigenomic analysis
including ATAC-seq and ChIP-seq, and single cell RNA-sequencing in postmortem human brain samples to further understand the roles of different neural cell types – including neurons, astrocytes, oligodendrocytes, and microglia – in AD-related neurodegeneration.
currently applying techniques such as Hi-C to investigate how DSB formation impacts the topology of the genome and how DSBs accumulation leads to neuronal demise.
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