The SIG meets regularly to evaluate the risk posed by SARS-CoV-2 variants circulating in the United States and to make recommendations about the classification of variants
Given the continuous evolution of SARS-CoV-2 and our understanding of the impact of variants on public health, variants may be reclassified based on their attributes and prevalence in the United States.
classify SARS-CoV-2 sequences according to their genetic relatedness.
Not every SARS-CoV-2 virus is assigned its own clade by Nextclade.
corresponds to the group of Pango lineages that descended from BA.4,
a natural process called “recombination
its ability to spread, cause severe disease or make treatments or vaccines less effective.
CDC scientists evaluate and monitor the new recombinant just like any other variant lineage
VOI include variants that have:
changes to receptor binding domain
reduced neutralization by antibodies generated against previous infection or vaccination.
educed efficacy of treatments, or tests.
predicted increase in transmissibility or disease severity
cause of an increased proportion of cases or unique outbreak clusters.
limited prevalence or expansion
variant of interest,
increase in transmissibility.
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