Coronavirus Disease 2019 (COVID-19)

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Top Highlights

• BA.2

• The SIG meets regularly to evaluate the risk posed by SARS-CoV-2 variants circulating in the United States and to make recommendations about the classification of variants

• Given the continuous evolution of SARS-CoV-2 and our understanding of the impact of variants on public health, variants may be reclassified based on their attributes and prevalence in the United States.

• B.1.1.529,

• classify SARS-CoV-2 sequences according to their genetic relatedness.

• Not every SARS-CoV-2 virus is assigned its own clade by Nextclade.

• corresponds to the group of Pango lineages that descended from BA.4,

• a natural process called “recombination

• its ability to spread, cause severe disease or make treatments or vaccines less effective.

• CDC scientists evaluate and monitor the new recombinant just like any other variant lineage

• VOI include variants that have:

• changes to receptor binding domain

• reduced neutralization by antibodies generated against previous infection or vaccination.

• educed efficacy of treatments, or tests.

• predicted increase in transmissibility or disease severity

• genetic markers

• cause of an increased proportion of cases or unique outbreak clusters.

• limited prevalence or expansion

• variant of interest,

• increase in transmissibility.