Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands - PIIS1934590923003600.pdf

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• Bcl2 family members

• erythroid cells to provide oxygen transport

• sterile

• expansion during fetal development, functional quiescence in adulthood, and decline upon aging

• cell cycle regulation, inflammatory response pathways, epigenetic changes, and metabolic regulation

• establishing the hematopoietic compartment.

• higher proliferative capac- ity and greater repopulation ability

• active cell cycle engagement

• G1/S/G2-M phase

• anabolic demands

• a greater reliance on oxidative metabolism

• ncreased mito- chondrial mass and oxygen consumption necessitating the buff- ering of reactive oxygen species by autophagic degradation

• elevated protein synthesis

• suppress stress responses triggered by unfolded proteins

• tumor necrosis factor alpha (TNF-a)

• Notch and nuclear factor kB (NF-kB) signaling

• Interferon (IFN)

• inflammatory cytokine expression mediated by the commensal gut microbiome

• ascularized FL niche

• Nestin+ NG2+ pericytes promoting HSC expansion