Allosteric sodium in class A GPCR signaling
www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(14)00048-6
1 Users
0 Comments
2 Highlights
0 Notes
Tags
Top Highlights
the Na+ and water pocket collapses in size from ∼200 to <70 Å3 due to the activation-related movements of the TM helices.
Conformational analysis and molecular dynamics studies for A2AAR suggest that such a collapsed pocket in the active-like states of GPCRs is incompatible with Na+ binding [30].
Ready to highlight and find good content?
Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.