5. Great differences in sensitivities are observed amongst various species; rodents, especially mice, show an increased sensitivity to the acute toxicity of ivermectin, whereas primates including humans possess a relatively lower degree. Therapeutic doses are usually well tolerated in all species. Subpopulations with a particularly high sensitivity have been identified in dogs (eg collies), however the extensive and safe use in human medicine suggests
that for the safety evaluation of residues with regard to the consumer this aspect is not relevant
6. Teratogenic effects in laboratory animals occur only at maternotoxic doses. Studies on mutagenicity and carcinogenicity (with abamectin) are negative.
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