Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects
www.frontiersin.org/articles/10.3389/fimmu.2020.585880/full
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TNFR1 is a death receptor, as its structure includes a death domain (DD), that is constitutively expressed on most cell types and is activated by TNFα in either its membrane-bound (mTNFα) or soluble (sTNFα) forms (1–3). Following activation by binding TNFα, intracellular signaling via TNFR1 is initiated via its DD (4).
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