No causal association between COVID-19 and sepsis: a bidirectional two-sample Mendelian randomization study

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Top Highlights

• Several reports have shown since the beginning of the pandemic that while COVID-19 has certain distinctive characteristics, many of its acute signs are comparable to sepsis brought on by other viruses

• This was the first research to use a variety of complementary MR techniques to examine the bidirectional causal relationship between sepsis and COVID-19.

• While managing secondary sepsis is still important, our findings underscore the need to better understand the distinct mechanisms leading to critical COVID-19 pneumonia apart from sepsis.

• According to information acquired from multiple cohorts, respiratory failure and the start of sepsis are the leading causes of mortality from COVID-19

• The results suggested that Very severe respiratory confirmed COVID-19(VSRC), hospitalized COVID-19(HC) and Infected COVID-19(IC) had no causal influence on sepsis risk using the inverse variance weighted (IVW) technique

• Sepsis and COVID-19 have a well-established observable relationship. Whether COVID-19 increases the likelihood of developing sepsis and whether patients with sepsis are at increased risk for COVID-19 infection is unknown.

• here was no causal effect of sepsis on the risk of VSRC, HC and IC

• Severe COVID-19 has been linked in several studies to older age, male sex, and a number of comorbidities, including obesity, type 2 diabetes, cardiovascular disease, and hypertension

• Bacterial pathogens are frequently implicated in the development of sepsis, but other pathogens such as viruses, fungi, and bacteria can also cause it

• Sepsis is one of the main causes of infection-related death and is a severe, potentially fatal clinical syndrome.

• SARS-CoV-2 and viral sepsis: observations and hypotheses.

• (19)

• Although the above study shows that there is an association between SARS-CoV-2 and sepsis, whether SARS-CoV-2 has a causal relationship with the occurrence and development of sepsis remains to be further verified.

• The purpose of this study is to investigate the bidirectional causal effects between SARS-CoV-2 infection and sepsis development.

• There have been earlier epidemiological studies that found a connection between sepsis and COVID-19.

• According to a recent meta-analysis, a sizable majority of hospitalized patients have COVID-19-related sepsis based on Sepsis-3; 77.9% of adult patients in the ICU had viral sepsis

• (31).

• As a result, drawing conclusions about the causes of COVID-19 and sepsis merely from past research is challenging.

• COVID-19 severity

• Very severe respiratory confirmed COVID-19(VSRC)