Lower Airway Microbiota
www.frontiersin.org/articles/10.3389/fped.2019.00393/full
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在生命的最初几周内形成气道微生物群与免疫系统耐受性的早期发展有关，包括诱导调节细胞和先天免疫细胞因子（白细胞介素-4、-5 和 -13）的特异性遗传激活
然后，微生物刺激可以影响肺粘膜屏障的成熟，与环境接触的免疫调节表面的稳态，从而扩大调节性肺间质巨噬细胞并影响对过敏性哮喘的易感性
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