Research
www.graybiel-lab.com/research.html
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iscovering neural mechanisms underlying habit learning, motivation, motivationally based decision-making, and how these networks translate their signals to the action systems of the brain to build up our behaviors.
The lab emphasizes data analysis and computational analytic methods to help in interpreting findings.
whose activity is disturbed in human disorders ranging from Parkinson’s disease to OCD, autism spectrum disorders, depression, stress-related disorders, and addictive behavior
the lab works collaboratively with other scientists to match the lab’s tasks to tasks that can be performed by human subjects, including patients;
engineering projects
To work on these systems, lab members use many state-of-the art methods and engineer mice so that precise biological mechanisms can be addressed
The lab is focused on experiments on the brains of rodents and non-human-primates performing tasks involving reward-based learning, decision-making under conditions of motivational conflict (such as cost-benefit conflict), and other motivational contexts using electrophysiology, optogenetics, chemogenetics, calcium imaging, photometric methods, dopamine-monitoring, immunohistochemistry, along with molecular methods including mouse engineering to detect specific neural populations in neocortex and striatum.
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