Reviewing David Sinclair’s First Lifespan Book | Lifespan.io
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AMPK (AMP activated protein kinase) activates glucose and fatty acid metabolism when cellular energy reserves get low
loss of information in the epigenome is the universal cause of aging
DNA is a form of digital information that remains sufficiently intact to reset cells to a youthful phenotype
What changes is the placement of methyl groups in regions of DNA that block gene expression. This is a form of analog information
regulation of gene expression using methyl groups is what defines the epigenome
methylation changes are what cause the emergence of the hallmarks of aging
Longevity genes, when expressed, produce longevity factors
sirtuins, FOX proteins, NAD+, and target of rapamycin (TOR)
Sirtuins are a family of seven proteins that regulate inflammation, energy metabolism, and DNA repair
function in the presence of NAD, and suboptimal sirtuin expression can occur if NAD+ is not produced in sufficient amounts
NAD+ production tends to decrease with increasing age
coenzyme helps turn macronutrients like carbohydrate, fat, and protein into the energy necessary for driving cellular processes
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