STAT1 phosphorylation at Y701
inflammatory pathway activation after ionizing radiation
failure of non-homologous end-joining (NHEJ) DSB repair should amplify the response
nhibition of DNA-dependent protein kinase catalytic subunit (DNA-PKi) or CRISPR–Cas9 knockout of multiple NHEJ components diminished STAT1 activation
DSB-induced STAT1 activation correlated with the appearance of aberrantly shaped nuclei and micronuclei
As micronuclei are by-products of mitotic progression, this suggested that STAT1 activation occurred following mitosis
mitotic entry is a gateway to inflammatory signalling for diverse DSB-inducing stimuli
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