doxycycline inhibits the cleavage and processing of bacterial rRNA transcripts/precursors, leading to impaired formation of mature rRNAs, and the consequent inhibition of protein synthesis for which the tetracycline group of antibiotics are renowned.
Doxycycline is a member of the broad spectrum group of antibiotics known as the tetracyclines. The tetracyclines are known to inhibit bacterial protein synthesis by binding to the 16S ribosomal RNA (rRNA) and inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex
It is interesting to note that the inhibitory effects of doxycycline on rRNA processing were observed at the effective antibacterial concentrations of the drug. MIC of doxycycline for E. coli K-12 a
The recovery from the inhibitory effects of the drug on the formation of mature ribosomal RNA with time supports the bacteriostatic mode of action of the tetracyclines.
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