Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation - Nature Immunology
www.nature.com/articles/s41590-022-01185-3
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During the inflammatory response, succinate levels increase, and the CoQ pool can become reduced19. This results in reverse electron transport (RET) from CoQH2 to NAD+ at mitochondrial complex I (Fig. 1a)—a process that generates high levels of superoxide (O2•−)
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