20/25 to 20/200, usually 20/60 to 20/100.
lack of dermal and ocular pigment as OCA
OCA is a group of phenotypically similar genetic disorders derived from errors in melanin synthesis
spectrum of severity depending upon the subtype of OCA
OCA1 to OCA7
1 in 40,000 worldwid
most common forms in America and China (70%
derived from neural crest ectoderm during embryonic development and migrate into the skin, eyes, hair, and inner ear
melanin-producing organelles (melanosomes)
two most common forms of melanin are eumelanin and pheomelanin
ynthesis of eumelanin over pheomelanin is stimulated by activation of melanocortin one receptors (coded by the MC1R gene) on melanocytes
black or brown coloratio
ultraviolet radiation B
ot UV protectiv
red or blond hair
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