Pathophysiology Of Asthma - StatPearls - NCBI Bookshelf

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• sustain inflammation

• These cells, in turn, contract the smooth muscle and cause airway tightening

• early phase is initiated by IgE antibodies that are sensitized and released by plasma cells

• antibodies respond to certain triggers in the environment

• IgE antibodies then bind to high-affinity mast cells and basophils

• When a pollutant or risk factor gets inhaled, the mast cells release cytokines and eventually de-granulate

• Released from mast cells are histamine, prostaglandins, and leukotrienes

• These cells, in turn, contract the smooth muscle and cause airway tightening

• Th2 lymphocytes play an integral role where they produce a series of interleukins (IL-4, IL-5, IL-13)

• sustain inflammation

• IL-3 and IL-5 help eosinophils and basophils survive. IL-13 attributes to remodeling, fibrosis, hyperplasia