PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
www.ncbi.nlm.nih.gov/pmc/articles/PMC5078108/
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PI3K is generally classified into three classes according to their substrate specificity and subsequence homology, among which, the class I is most vital to the tumorigenesis. Class I consisted of a catalytic subunit p110 (α, β, γ) and a regulator subunit p85. A
The subsequent conformation change will release the catalytic subunit p110
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