Trametinib: A Targeted Therapy in Metastatic Melanoma
www.ncbi.nlm.nih.gov/pmc/articles/PMC6570520/
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elective inhibitor of MEK1/MEK2 activation and kinase activity
However, MEK inhibitors suppress ERK signaling in both tumor and normal cells, and therefore on-target toxicities limit the doses that can be safely administered
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