www.ncbi.nlm.nih.gov/pmc/articles/PMC6785028/
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psilocybin
Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin’s active metabolite, psilocin.
irst time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans.
first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans.
We here show that psilocybin ingestion of between 3 and 30 mg is associated with dose-dependent occupancy of cerebral 5-HT2ARs.
5-HT2AR occupancy are positively associated and the relationship conforms with a single-site binding mode
psychedelic effects of psilocybin
are closely
correlated with psilocin stimulation of the 5-HT2AR
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