Expression and clinical significance of MAPK and EGFR in triple-negative breast cancer
www.ncbi.nlm.nih.gov/pmc/articles/PMC7038935/
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MAPKs primarily regulate the functions of other proteins through phosphorylation, and play an important role in the occurrence, development and metastasis of multiple tumors
expression levels of MAPK and EGFR, and the correlation between MAPK and EGFR expression was evaluated using Cramer's V test.
Moreover, MAPK expression was associated with that of EGFR in TNBC tissues.
EGF, and subsequently activating multiple signal transduction pathways; these include the MAPK/ERK and phosphoinositide 3-kinase (PI3K)/Akt pathways, which promote tumor angiogenesis, proliferation, invasion and metastasis
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