Muscle Strength in Transgender Women After Long-Term Hormone Therapy: A Cross-Sectional Study

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• The effects of prior exposure to testosterone during puberty on the performance of transgender women (TW) undergoing physical effort are not well known

• All TW were non-gonadectomized subjects and were in estrogen plus cyproterone acetate therapy

• Mean total testosterone (ng/dL) levels of TW, CW and CM were 83.5, 20.5 and 480.5 at the time of the study, respectively

• The mean maximum strength was 31,9 kg (SD±2.4) in TW, 29.2 kg (SD±4.4) in CW, and 47.5 (SD±8.6) in CM

• FFM, a mean of 0.54 was observed in the TW group, and 0.76 in the CW and CM

• The expression of muscle strength/FFM is the same in CM and CW, which suggests that the innate quality of the muscles as well as their motor control is similar in these groups

• After GAHT muscle strength of TW is equal of CW.

• There is a decrease in the functionality of the muscular unit in producing strength in this group of TWs