In subjects with type 2 diabetes, KD may be associated with positive effects on some cardiovascular risk factors [9–13]. Of note, the utilization of ketone bodies has shown protective cardiovascular effects in non-diabetic individuals
Nutrition therapy guidelines often emphasize a reduction in the excessive amounts of carbohydrates,
ketosis secondary to the severe carbohydrate restriction (<50 g/day) and the excess of free fatty acids.
induces a radical change in energy metabolism with an increase in fatty acid oxidation in the liver and production of ketone bodies
findings that need to be confirmed in individuals with diabetes mellitus.
concerns have been raised about long-term adverse effects, particularly lipid metabolism and fatty liver disease, because of the high fat intake;
The chance of lowering HbA1c <7% was two-fold higher with KD compared to a standard hypocaloric diet
The same authors even reported remission in 10 of 24 participants with T2D (HbA1c <5.7% and no medication) after 15 months .