Hydroxychloroquine (HCQ) is a cornerstone of SLE therapy and a very important factor especially in a discussion about remission. Consistent antimalarial treatment reduced the risk of flares  and, more importantly, mortality [44, 45], and during remission is a beneficial and desirable treatment. The definitions of remission allow the use of chloroquine (CQ) or HCQ for disease activity control.
Chronic GCs treatment is the most dangerous predictor of poor prognosis, an independent risk factor of organ damage in the course of SLE.
The aggressive effective treatment of SLE flares by a high dose