Solid pseudopapillary neoplasm
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F:M = 10:1
Low malignant potential tumors with unclear cell of origin and pathogenesis
most cases are incidentally discovered on imaging
solid and pseudopapillary areas
intracytoplasmic hyaline globules (PAS+ and diastase resistant, positive for alpha-1-antitrypsin) and perinuclear vacuoles
third to fourth decade of life (mean age 35 years)
Papillary fronds on myxoid or hyalinized vascular stalk lined by poorly cohesive, uniform cells with nuclear grooves comprising solid and cystic areas beta catenin nuclear / cytoplasmic positive
CD10 (63%)
E-cadherin (
Beta catenin
progesterone receptor
synaptophysin (55%)
Cytokeratin (52%)
Chromogranin A (positive in only 9%)
Estrogen receptor
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