Recent advances in dengue pathogenesis and clinical management
www.sciencedirect.com/science/article/pii/S0264410X15013936?via%3Dihub
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lovastatin, one of the statin group of lipid-lowering drugs.
early prednisolone
effective and safe antiviral therapy, if given orally to outpatients with dengue, might be expected not only to decrease the burden on healthcare services in endemic areas, but potentially might also reduce on-going transmission of the virus to mosquitoes and new human hosts
chloroquine, balapiravir (a polymerase inhibitor developed for treatment of the related virus, hepatitis C) and celgosivir (a cellular glucosidase inhibitor)
no evidence in any of these trials of a benefit in reducing plasma viremia or in preventing the development of complications
corticosteroids
n patients with DSS
with the primary goal of assessing safety during the phase of active viral replication
trend to hyperglycaemia in high-dose steroid recipients
no evidence of efficacy in preventing DSS
primary goal of assessing safety during the phase of active viral replication
no evidence of harm with early prednisolone use
prophylactic platelet transfusion
Thrombocytopenia is frequently observed in patients with dengue, but is rarely accompanied by clinically relevant bleeding
risks of fluid overload, allergic reactions and transmission of blood–borne pathogens
mast cell mediators play a role in dengue pathogenesis as corticosteroids have no effect on mast cell degranulation
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