α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
www.sciencedirect.com/science/article/pii/S2211124723012561?via%3Dihub
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α-Syn has been shown to positively correlate with PI(4,5)P2 levels at cellular membranes
α-Syn fibril treatment or α-SynA53T favor ARF6-dependent recruitment of PIP5K1γ to increase PI(4,5)P2
We propose that α-Syn fibrils facilitate ARF6-dependent recruitment of PIP5K1γ to catalyze the production of PI(4,5)P2 and the seed aggregation of monomeric α-Syn at the PM in models of PD
recruitment of a PI(4,5)P2 5-phosphatase to decrease PM PI(4,5)P255,64,65 reduced α-SynA53T aggregates, whereas recruitment of a PI(4)P 5-kinase to increase PM PI(4,5)P2 increased α-SynA53T aggregates
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