As an upper pathway, EGFR activation is a prerequisite for downstream activation . The role of the RAS protein in the activation of Akt is crucial . Two downstream pathways are closely involved in cell proliferation .
The results showed that neither cetuximab nor MEK inhibitor inhibited Akt activity, indicating that cancer-causing tumors with K-RAS mutations can be effectively resolved by simultaneously blocking the PI3K-Akt and RAS–ERK pathways.
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