Cancer Engineering

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Top Highlights

• tumor cell evolution and to predict gene function

• Our research also spans cancer evolution, immuno-oncology, translational genomics, biomarker discovery, tumor metabolism and genetic ancestry effects

• to develop new technologies and use engineering techniques to solve fundamental problems in biology and to better understand, diagnose, and treat cancer.

• believe in the potential of cancer engineering to transform diagnosis and treatment.

• nanotechnology, imaging, immuno-engineering, integrative computational biology, and genetic engineering, along with unparalleled access to cutting-edge tools such as nanomaterials, CRISPR, organoids, atomic force microscopes, and 3D printers

• a variety of backgrounds, including those with an engineering or physical science focus.

• Researchers are developing novel nanomaterial delivery platforms using biomaterial scaffolds, inorganics, and nanocarbons for the targeted delivery of small molecule and biologic therapies, including RNA.

• how to target the delivery of nanotherapeutics into cancer

• prostate-specific membrane antigen (PSMA) and P-selectin modes of targeting,

• We study and leverage nanotechnology and engineer biomaterials to make foundational biological discoveries in living cells and tissues,

• advanced imaging and probe development, utilizing components such as small molecules, proteins, and nanoparticles

• Our research efforts have led to clinical translation for a number of new cancer imaging probes,

• Memorial Sloan Kettering faculty were the first to report the potential of chimeric antigen receptor (CAR) T cells to induce remissions in adult patients with refractory acute lymphoblastic leukemia

• the Computational and Systems Biology Program and the Computational Oncology Program

• d major discoveries in biology and oncology and developed next generation computational tools and platform

• statistical methods to identify cell states

• how they change across developmental time or under disease conditions

• nd to discover the genes that drive these change

• , RNA splicing and regulation, and how certain proteins bind specifically to DNA or RNA.

• MSK-SPECTRUM (Spatio-temporal evolution of cancer traced using multimodalities)