More aggressive hypotensive therapy is both unnecessary and may reduce BP below the autoregulatory range, possibly leading to ischemic events
apidly lower the mean arterial pressure by approximately 10 to 15 percent in the first hour
no more than 25 percent compared with baseline by the end of the first day of treatmen
with the systolic pressure being gradually reduced to <130 mmHg and the diastolic pressure being gradually reduced to <80 mmHg over two to three months.
e initial reduction in BP is often associated with a modest worsening of kidney function; this change, however, is typically transient as the vascular disease tends to resolve and kidney perfusion improves over one to three months
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